Air is mostly nitrogen and oxygen, averaging about 29 g/mol. Carbon dioxide is heavier at about 44 g/mol, and the cloud also carries heavy ash. Heavier mixtures sink — just like water sits below oil — so the deadly layer pools at ground level, exactly where Owen is running.
Sulfur dioxide is an acid anhydride — an acid waiting for water. Owen's lungs are warm and wet, so it reacts the instant he inhales:
A hot glass dish dropped in ice water cracks because the outside shrinks while the inside is still expanded. But the sphere never touches lava — only hot gas — so the temperature gap is small, and its material (transparent aluminium, ALON) is specifically chosen to resist heat shock.